Beilstein J. Org. Chem.2022,18, 1116–1122, doi:10.3762/bjoc.18.114
electrochemical production of cyclopropane derivatives is an environmentally friendly and easy to perform synthetic procedure.
Keywords: alkyl2-chloroacetates; cyclopropane derivatives; divided cell; electro-reduction; Introduction
In organic chemistry, cyclopropanes and their related compounds have been
derivatives could be formed in moderate yields through the electrochemical reduction [13][14][15][16][17][18][19][20][21] of alkyl2-chloroacetates in a divided cell (Scheme 1, reaction 4). The in Abushanab’s study utilized metal lithium is one of the rarest and most expensive metals. In addition, the
-chloroacetates to cyclopropane derivatives has been developed. The reaction has been optimized, the scope and limitations have been investigated. Scale-up reactions were performed and satisfactory yields obtained. The generation of an EGB of the enolate ion from alkyl2-chloroacetates is indicated. The current
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Graphical Abstract
Scheme 1:
Formations of 1,2,3-trialkyl cyclopropanetricarboxylates. Previous reports (reactions 1–3) and this...